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KMID : 0981820090290060510
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Korean Journal of Laboratory Medicine
2009 Volume.29 No. 6 p.510 ~ p.514
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Near-tetraploidy Acute Myeloid Leukemia with RUNX1-RUNX1T1 Rearrangement Due to Cryptic t(8;21)
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Im Mi-Jeong
Chang Yoon-Hwan
Hong Young-Joon
Hong Seok-Il
Lee Jin-Kyung
Lee Dong-Young
Kang Hye-Jin
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Abstract
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Tetraploidy or near-tetraploidy is a rare cytogenetic abnormality found in AML, and is divided into primary and secondary forms. The secondary tetraploidy or near-tetraploidy found in AML is known to be specifically associated with t(8;21). In this case report, FISH analysis detected RUNX1-RUNX1T1 gene rearrangement in the absence of cytogenetic abnormality of t(8;21), which suggests the presence of unvailed t(8;21). This is the first case report of tetraploidy or near-tetraploidy AML with cryptic RUNX1/RUNX1T1 in Korea. Although the prognosis of tetraploidy or near- tetraploidy with t(8;21) is known to be poor, this patient shows a relatively good clinical course compared to other reported cases.
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KEYWORD
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Tetraploidy, Near-tetraploidy, AML, RUNX1-RUNX1T1, Cryptic t(8, 21)
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